| Pair Name | Thymoquinone, Topotecan | ||
| Phytochemical Name | Thymoquinone (PubChem CID: 10281 ) | ||
| Anticancer drug Name | Topotecan (PubChem CID: 60700 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Thymoquinone, Topotecan | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | U-937 | Adult acute monocytic leukemia | Homo sapiens (Human) | CVCL_0007 |
| Result | Thymoquinone, when combined with topotecan in noncytotoxic doses, produced synergistic antiproliferative and proapoptotic effects in AML cells | |||
| No. | Title | Href |
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| 1 | Antiproliferative and proapoptotic effects of topotecan in combination with thymoquinone on acute myelogenous leukemia. Clin Lymphoma Myeloma Leuk. 2014 Sep;14 Suppl:S46-55. doi: 10.1016/j.clml.2014.04.014. Erratum in: Clin Lymphoma Myeloma Leuk. 2015 Jun;15(6):384. | Click |
